RAF Typhoon FGR4s have operated alongside French warplanes in a coordinated attack on an hidden munitions depot in Syrian territory used by the Islamic State group (IS), as stated by the British defence ministry.
The site, located using intelligence, was believed to be containing munitions and bombs, the statement said, and was positioned in hills just to the north of the ancient city of Palmyra in central Syria.
"The RAF jets employed Paveway IV guided bombs to target a series of entry passages providing entry to the depot... preliminary assessments suggest the strike was effective," the ministry announced.
There was no sign of any harm to civilians in the operation late on Saturday and each participating jet returned to base without incident, the defence officials confirmed.
The Typhoon fighters were supported by a Voyager refuelling tanker.
IS - alternatively referred to as ISIS - enforced jihadist rule over significant areas in both Syria and Iraq until 2019.
"This action demonstrates British leadership, and determination to operate in unison with our allies, to eliminate any revival of the terrorist group and their harmful and extremist ideologies in the region," the British Defence Secretary the Defence Secretary said.
UK warplanes have performed surveillance missions over Syrian airspace to "forestall any efforts to regroup" of Islamic State after its routing at the battle of Baghuz in 2019, the ministry said.
"I want to thank every member of the UK armed forces participating in this mission for their skill and their courage," Healey added. "They were part of a great many British troops stationed over the festive period. This operation, to take out terrorist threats who endanger our way of life, highlights how British military are prepared to act, throughout the year, protecting the UK within its borders and influential overseas."
During December, the American forces conducted what it called a "large-scale strike" against Islamic State objectives in Syria, following an attack resulted in the deaths of two US servicemembers and a local interpreter in the Palmyra area.
The United Nations says Islamic State still has an estimated 5,000 to 7,000 fighters in Iraq and Syria.